Xaiv txoj cai PVP yuav tsum xav txog ntau yam, suav nrog cov kev cai ua haujlwm, thiab lwm yam ntawm no yog qee yam kev qhia ntawm PVP:
1. Molecular hnyav:
- PVP muaj cov hnyav sib txawv, xws li los ntawm ntau txhiab tus lab. Molecular qhov hnyav cuam tshuam nws solubility, viscosity, thiab zaj duab xis-ua cov khoom. Piv txwv li, qis molecular hnyav pvp (K15, K30) yaj tau sai thiab yog qhov haum raws li cov phau ntawv sau thiab tsis sib haum; High molecular hnyav pvp (k90, k020) muaj cov yeeb yaj kiab zoo nkauj thiab viscosity thiab tsim nyog ua zaj duab xis-ua tus neeg sawv cev.
2. Cov qauv tshuaj:
- PVP muaj ntau yam ntawm derivatives, xws li PVP-VA (polyvidone-acetate copolymer) thiab PVP / VA coploymer. Cov derivatives muaj txawv solubility thiab zaj duab xis-ua cov khoom. Piv txwv li, PVP-VA yog ntau soluble hauv cov kuab tshuaj organic thiab yog qhov haum rau kev npaj cov ntsiab lus.
3. Solubility:
- Xaiv cov pvp hom raws li koj daim ntawv thov nruab nrab (dej, Organic kuab, thiab lwm yam). Qee cov PVPS yog yooj yim soluble hauv dej, thaum lwm tus yooj yim solvle hauv cov kuab tshuaj organic.
4. Biocompatibility thiab kev nyab xeeb:
- Xyuas kom meej tias xaiv pvp hom ua tau raws li biocompatibility thiab kev yuav tsum muaj ntawm kev lag luam kev lag luam. FDA-Pom Zoo PvP hom (xws li Povidone USP / NF) yog qhov tsim nyog rau kev sib cuag nrog tib neeg lub cev lossis rau kev npaj rau ntawm qhov ncauj.
5. Stability:
- Xav txog qhov kev ruaj ntseg ntawm PVP hauv kev npaj, nrog rau kev ua siab ntev rau ph, kub thiab lub teeb. Xaiv lub PVP hom nrog zoo stability tuaj yeem txhim kho lub txee txee ntawm kev npaj.
6. Tus nqi-ua tau zoo:
- Xaiv tus nqi pvp zoo nqi raws li kev siv nyiaj thiab tus nqi them tau zoo. Cov nqi ntawm pvp nrog cov nyom molecular thiab derivatives sib txawv heev.
7. Daim Qauv Hom:
- Xaiv cov PvP tsim nyog raws cov hom phiaj tsim qauv (ntsiav tshuaj, tsiav tshuaj, tshuaj pleev, tshuaj, thiab lwm yam). Cov qauv sib txawv muaj sib txawv rau cov solubility, viscosity thiab zaj duab xis-tsim cov khoom ntawm PVP.
8. Cov Khoom Siv Tshuaj:
- Txiav txim siab cov tshuaj uas muaj cov tshuaj (xws li solubility, ruaj khov, thiab lwm yam) thiab xaiv pvp hom uas tau sib xws nrog nws. Qee cov tshuaj yuav cuam tshuam nrog cov hom PVP tshwj xeeb.
9. Tso cov khoom:
- Rau kev tswj hwm los yog kev tso tawm cov yeeb yaj kiab, xaiv cov pvp hom uas tuaj yeem hloov cov tshuaj tso tawm tshuaj. Molecular hnyav thiab kev xav tau tuaj yeem cuam tshuam cov khoom siv yeeb tshuaj.
10. Cov Cai Tswj:
- Xyuas kom meej tias cov pvp hom sib ntsib cov qauv kev tswj hwm thiab cov qauv zoo, xws li USP / NF, EP, EP, EP, ELS Pharpacopoeia cov qauv.
Hauv cov ntsiab lus, xaiv txoj cai PVP hom yuav tsum muaj kev txiav txim siab ntawm ntau yam thiab hnyav lawv raws li cov kev cai siv tau. Nws raug nquahu kom ua haujlwm nrog cov chaw muab khoom lossis cov kws tshaj lij los txiav txim siab PVP hom ntawv rau ib daim ntawv thov tshwj xeeb.
