N Vinyl 2 Pyrrolidone 616-45-5

2- Hloov cov khoom lag luam ntawm txoj haujlwm 1 thiab 4 ntawm lub nplhaib pyrrolidone thiab lawv cov txheej txheem synthesis

Kev hloov pauv ntawm txoj haujlwm 4 ntawm 2-pyrrolidone tuaj yeem tsim ntau cov tshuaj siv tshuaj. Cov piv txwv classic suav nrog kev tsim cov tshuaj tiv thaiv kab mob HIV. Feem ntau, kev tsim tshuaj tiv thaiv kab mob HIV tuaj yeem pib los ntawm peb yam: ⑴ Tiv thaiv kev khi ntawm virions rau T-4 lymphocytes; ⑵ inhibiting qhov rov qab transcriptase ntawm tus kab mob; ⑶ Inhibiting HIV kab mob protease. Cov tshuaj tiv thaiv kab mob uas twb muaj lawm tuaj yeem muab faib ua ob pawg: thim rov qab transcriptase inhibitors thiab protease inhibitors. Ntawm lawv, thim rov qab transcriptase inhibitors tuaj yeem muab faib ua nucleoside thim rov qab transcriptase inhibitors thiab non-nucleoside thim rov qab transcriptase inhibitors. Txij li thaum pib ntawm cov tshuaj tiv thaiv kab mob HIV zidovudine hauv xyoo 1980s, thawj zaug kev siv tshuaj kho mob ib leeg rau cov neeg mob HIV yog qhov pib tsis zoo, thiab tom qab ntawd kev siv tshuaj sib xyaw ua ke tau txais kev pom zoo, muaj txiaj ntsig zoo. Raws li kev pom ntawm cov tshuaj tiv thaiv kab mob HIV nce ntxiv, kev txhim kho cov tshuaj tiv thaiv HIV tshiab yuav tshwm sim. Ib tug series ntawm phenyl-substituted 2-pyrrolidone tebchaw tau tsim thiab synthesized, thiab lawv cov kev tiv thaiv kab mob HIV tau raug soj ntsuam nyob rau hauv thiaj li yuav nrhiav tau ib chav kawm ntawm zoo reverse transcriptase inhibitors.

Hloov cov khoom ntawm txoj haujlwm 1 thiab 5 ntawm 2-pyrrolidone

2-pyrrolidone derivatives uas tuaj yeem ua raws li cov tshuaj potassium channel blockers tau ua tiav tiav. Cov tshuaj no yog tshwj xeeb tshaj yog haum raws li antiarrhythmic active cov khoom xyaw, tshwj xeeb tshaj yog rau kev kho mob thiab kev tiv thaiv ntawm atrial arrhythmias, xws li atrial fibrillation (AF) los yog atrial flutter.

Hloov cov khoom ntawm ntau txoj haujlwm ntawm 2-pyrrolidone nplhaib

Feem ntau, kev hloov pauv ntawm ntau txoj haujlwm ntawm 2-pyrrolidone nplhaib tuaj yeem ua tau raws li qhov xav tau ntawm ntau yam kev ua haujlwm tshuaj. Monoamine oxidase (MAO, EC) yog ib qho flavonoid uas ua rau oxidative deamination ntawm endogenous monoamine neurotransmitters xws li dopamine, 5-hydroxytryptamine, epinephrine los yog norepinephrine thiab kab ntau ntawm amines xws li phenylethylamine, nrog rau ntau tus exogenous. amines. Ib daim ntawv patent tau tsim los ua ke ntawm cov pyrrolidone derivatives uas tuaj yeem ua raws li MAOB inhibitors.

Cim npe nrov: n vinyl 2 pyrrolidone 616-45-5, Tuam Tshoj n vinyl 2 pyrrolidone 616-45-5 manufacturers, lwm tus neeg, Hoobkas