Crospovidone Vs Copovidone 25249-54-1

pients thiab active cov khoom xyaw muaj zoo heev compatibility. Cov tshuaj uas muaj PVPP ntsiav tshuaj disintegrants tuaj yeem siv cov txheej txheem ntau lawm ntawm cov ntsiav tshuaj, suav nrog kev sib xyaw ncaj qha, Nws yog ib qho yooj yim los tsim los ntawm kev txau, ziab thiab ntub granulation.Compressibility thiab adhesionCrospovidone nf muaj fluidity zoo heev thiab yas deformation, yog li lawv muaj adhesion zoo heev. Cov cuab yeej no muab cov compressibility zoo hauv kev txau, ziab, thiab ntub granulation. Ntxiv PVPP ntsiav tshuaj disintegrant rau cov ntsiav tshuaj, piv nrog cov hmoov txhuv nplej siab uas nquag siv, npaj cellulose thiab pectin tebchaw, lub hardness thiab abrasion tsis kam ntawm cov ntsiav tshuaj tsis cuam tshuam, thiab capping ntawm cov ntsiav tshuaj tsis txo. Crospovidone nf kuj tseem tuaj yeem siv tau zoo ua cov ntsiav tshuaj disintegrant hauv kev sib xyaw ncaj qha, tsis tas siv cov roj nplua nyeem lossis ntxiv cov binders.Capillary kev ua haujlwm thiab dej muaj peev xwm Kev tshawb nrhiav haujlwm tau pom tias PVPP ua cov ntsiav tshuaj disintegrant muaj kev ua haujlwm siab capillary thiab hydration muaj peev xwm, vim tias lawv cov cheeb tsam loj tshwj xeeb (nruab nrab 1.25 m2 / g) thiab qhov nqus dej tseem ceeb (siab thiab nqus dej sai), nce txog 60% lossis ntau dua). Vim tias lub siab sab hauv (qhov siab o) ntau dua lub zog ntawm cov ntsiav tshuaj, cov ntsiav tshuaj disintegrates tam sim ntawd. Thiab vim tias muaj cov hlua khi molecular ntawm cov kab sib txuas, thaum dej los yog cov kua dej nkag mus, lawv tau ncab los ntawm kev cuam tshuam tam sim ntawd thiab yuam kom sib cais tam sim ntawd. Raws li qhov tshwm sim ntawm qhov o, qhov ntim ntim nce (kwv yees li ob npaug hauv 5 feeb), yog li cov ntsiav tshuaj npaj nrog PVPP ntsiav tshuaj disintegrants disintegrate tam sim ntawd.

Xa kev nug

Khoom Taw qhia

Khoom:

pients thiab active cov khoom xyaw muaj zoo heev compatibility. Cov tshuaj uas muaj PVPP cov ntsiav tshuaj disintegrants tuaj yeem siv cov txheej txheem ntau lawm ntawm cov ntsiav tshuaj, suav nrog kev sib xyaw ncaj qha, nws yooj yim los tsim los ntawm kev txau, ziab thiab ntub dej granulation.

Compressibility thiab adhesion

Crospovidone nf muaj fluidity zoo heev thiab yas deformation, yog li lawv muaj adhesion zoo heev. Cov cuab yeej no muab cov compressibility zoo hauv kev txau, ziab, thiab ntub granulation. Ntxiv PVPP ntsiav tshuaj disintegrant rau cov ntsiav tshuaj, piv nrog cov hmoov txhuv nplej siab uas nquag siv, npaj cellulose thiab pectin tebchaw, lub hardness thiab abrasion tsis kam ntawm cov ntsiav tshuaj tsis cuam tshuam, thiab capping ntawm cov ntsiav tshuaj tsis txo. Crospovidone nf kuj tseem tuaj yeem siv tau zoo li cov ntsiav tshuaj disintegrant hauv kev sib xyaw ncaj qha, tsis tas siv cov roj nplua nyeem lossis ntxiv cov binders.

Capillary kev ua ub no thiab hydration muaj peev xwm

Kev tshawb fawb ua haujlwm tau pom tias PVPP raws li cov ntsiav tshuaj disintegrant muaj kev ua haujlwm siab capillary thiab muaj peev xwm hydration, vim tias lawv qhov chaw tshwj xeeb loj (nruab nrab 1.25 m2 / g) thiab qhov nqus dej tseem ceeb (siab thiab nqus dej sai), txog li 60% lossis ntau dua. ).

o thiab disintegration

PVPP muaj kev ua haujlwm siab capillary, yog li nws tuaj yeem nqus dej sai sai rau hauv cov ntsiav tshuaj. Vim tias lub siab sab hauv (qhov siab o) ntau dua lub zog ntawm cov ntsiav tshuaj, cov ntsiav tshuaj disintegrates tam sim ntawd. Thiab vim tias muaj cov hlua khi molecular ntawm cov kab sib txuas, thaum dej los yog cov kua dej nkag mus, lawv tau ncab los ntawm kev cuam tshuam tam sim ntawd thiab yuam kom sib cais tam sim ntawd. Raws li qhov tshwm sim ntawm qhov o, qhov ntim ntim nce (kwv yees li ob npaug hauv 5 feeb), yog li cov ntsiav tshuaj npaj nrog PVPP ntsiav tshuaj disintegrants disintegrate tam sim ntawd.

Organic peroxidecrospovidone sds yog qhov sib txawv ntawm cov thermoplastics, thermosetting resins thiab vulcanized roj hmab. Nws muaj lub cev qauv tab sis tsis yog tag nrho kev sib txuas. Qhov chaw sib txuas yog me me thiab tsis muaj qhov sib txuas loj loj xws li roj hmab vulcanized. Nyob rau hauv cov nqe lus ntawm kev ua tau zoo, nws muaj cov yam ntxwv ntawm tag nrho peb, uas yog, nws muaj ob qho tib si thermoplasticity, hardness, zoo hnyav kuj, siab elasticity thiab zoo heev tsis kub tsis kam. Txawm hais tias nws yog polyethylene high-density polyethylene los yog low-density polyethylene, tom qab crosslinking, nws tensile zog, tshav kub tsis kam, laus kuj thiab huab cua tsis kam, seem stability, kev nyuaj siab tawg kuj, puas kuj thiab hnyav kuj yog tag nrho cov kev txhim kho, thiab zoo heev creep kuj. Lub softening point ntawm cross-linked polyethylene tuaj yeem ncav cuag 200 degree, thiab cov cua sov tuaj yeem ncav cuag 140 degree. Tsis tas li ntawd, nws kuj muaj cov hluav taws xob rwb thaiv tsev zoo heev, tsis tshua muaj kub thiab hluav taws xob tiv thaiv. Cov khoom ntawm peroxide cross-linked polyethylene.

2pvpp

Khoom:

dawb los yog milky dawb dawb-ntws hmoov, yooj yim nqus dej noo, tsis muaj ntxhiab lossis tsw ntxhiab me ntsis, insoluble hauv dej, alkali, acid thiab feem ntau siv cov kuab tshuaj organic, muaj zog o kev ua tau zoo thiab complexation muaj peev xwm nrog ntau hom tshuaj.

Daim ntawv thov:

Vim tias qhov hnyav molecular hnyav thiab cov qauv sib txuas ntawm cov ntoo khaub lig-txuas povidone, nws yog insoluble hauv dej tab sis tuaj yeem txhawb kev nthuav dav ntawm nws cov qauv network thiab disintegrate thaum raug dej, thiab yog dav siv los ua ib qho disintegrant rau cov ntsiav tshuaj hauv tshuaj. , thiab yog dav siv los ua ib qho kev ncua stabilizer, ib tug complexing neeg sawv cev rau cov khoom xyaw tshuaj, thiab ib tug complexing neeg sawv cev rau tannins thiab polyphenols nyob rau hauv cov tshuaj cog